Physicians during the American Revolution titrated alcohol with opium for tuberculosis. The Greek physicians Dioscorides and Galien recorded the use of opium combined with cannabis for many therapeutic purposes. Various herbs such as Boswellia (frankincense) were used with opium in ancient times to make it more potent. This concept is known as “potentiation” and there are many examples of it throughout history. The oldest measure to either minimize the dosage or make an opioid more effective has been to add a chemical agent that makes the opioid act longer and stronger.
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May 2023
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